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Product Name
ZNF354A antibody
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Description
ZNF354A Rabbit Polyclonal antibody. Positive WB detected in DU 145 cells. Observed molecular weight by Western-blot: 69 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
EZNF antibody; HKL1 antibody; KID 1 antibody; KID1 antibody; TCF 17 antibody; TCF17 antibody; Transcription factor 17 antibody; zinc finger protein 354A antibody; Zinc finger protein eZNF antibody; ZNF354A antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ZNF354A recombinant protein (Accession Number: XM_047417644). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
DU 145 cells were subjected to SDS PAGE followed by western blot with Catalog No:117166(ZNF354A antibody) at dilution of 1:1000
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Background
ZNF354A, also called EZNF, KID-1 or TCF17, belongs to the Kruppel C2H2-type zinc-finger family of proteins that contain KRAB domains and act as transcriptional regulators. Expressed primarily in the adult kidney, ZNF354A is a transcriptional repressor that plays a role in late renal development and is suppressed after renal ischemia. The N-terminus of ZNF354A contains the KRAB domain which confers transcriptional repressor activity, while the C-terminus contains multiple Cys2His2-zinc fingers. ZNF354A is located in the nucleolus and is thought to specifically influence development of the proximal tubule by shutting off dispensable or inhibitory genes. Reduced ZNF354A expression prevents proper cell differentiation and may, therefore, be implicated in renal carcinoma.
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