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Product Name
ZMYND8 antibody
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Description
ZMYND8 Rabbit Polyclonal antibody. Positive WB detected in Transfected HEK-293 cells. Positive IP detected in HeLa cells. Positive IHC detected in human lung cancer tissue. Observed molecular weight by Western-blot: 150 kDa
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Tested applications
ELISA, IHC, IP, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
CTCL assOCiated antigen se14 3 antibody; KIAA1125 antibody; PRKCBP1 antibody; PRO2893 antibody; RACK7 antibody; ZMYND8 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ZMYND8 recombinant protein (Accession Number: BC030721). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:1000
IHC: 1:20-1:200
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Validations
Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:116943(ZMYND8 antibody) at dilution of 1:50 (under 10x lens)
Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:116943(ZMYND8 Antibody) at dilution of 1:1000
IP Result of anti-ZMYND8 (IP:Catalog No:116943, 3ug; Detection:Catalog No:116943 1:300) with HeLa cells lysate 920ug.
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Background
Regulation of neuronal gene expression is essential to nervous system development. REST (RE1-silencing transcription factor) regulates neuronal gene expression by interacting with a group of corepressor proteins including REST corepressors (RCOR). ZMYND8 bind to RocR2 and can function as transcriptional repressors. It is co-expressed with RCOR2 in the nervous system and overexpression of ZMYND8 inhibits neural differentiation. [PMID:20331974]
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