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Product Name
ZIP7 antibody
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Description
ZIP7 Rabbit Polyclonal antibody. Positive IHC detected in human kidney tissue, human placenta tissue. Positive IP detected in mouse brain tissue. Positive WB detected in mouse liver tissue, MCF7 cells, rat liver tissue. Observed molecular weight by Western-blot: 50kd,56kd
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
KE4 antibody; RING5 antibody; SLC39A7 antibody; Zinc transporter SLC39A7 antibody; ZIP 7 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ZIP7 recombinant protein (Accession Number: NM_006979). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:1000-1:10000
IP: 1:200-1:2000
IHC: 1:20-1:200
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Validations
mouse liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:117061(SLC39A7 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human kidney using Catalog No:117061(SLC39A7 antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human kidney using Catalog No:117061(SLC39A7 antibody) at dilution of 1:100 (under 40x lens)
IP Result of anti-SLC39A7 (IP:Catalog No:117061, 4ug; Detection:Catalog No:117061 1:500) with mouse brain tissue lysate 4000ug.
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Background
SLC39A7 represents solute carrier family 39 (zinc transporter), member 7
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References
- Grubman A, Lidgerwood GE, Duncan C. Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder. Acta neuropathologica communications. 2:25. 2014.
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- Grubman A, Pollari E, Duncan C. Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses? Metallomics : integrated biometal science. 6(4):932-43. 2014.
- Grubman A, James SA, James J. X-ray fluorescence imaging reveals subcellular biometal disturbances in a childhood neurodegenerative disorder. Chemical science (Royal Society of Chemistry : 2010). 5(6):2503-2516. 2014.
- Liu Y, Batchuluun B, Ho L. Characterization of Zinc Influx Transporters (ZIPs) in Pancreatic β Cells: ROLES IN REGULATING CYTOSOLIC ZINC HOMEOSTASIS AND INSULIN SECRETION. The Journal of biological chemistry. 290(30):18757-69. 2015.
- Kanninen KM, Grubman A, Caragounis A. Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis. Biology open. 2(6):635-46. 2013.
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