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Product Name
Zilovertamab vedotin reference antibody
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Description
Anti-ROR1 Antibody (Zilovertamab vedotin)
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Tested applications
ELISA
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Species reactivity
Human ROR1
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Isotype
IgG1
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Preparation
Recombinant expression and purified from CHO cells.
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Clonality
Monoclonal
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Formulation
0.1 M Pro-Ac, 20 mM Arg, pH 5.0
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Storage instructions
-80°C for 2 years under sterile conditions; -20°C for 1 year under sterile conditions; Avoid repeated freeze-thaw cycles.
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Validations
SDS-PAGE
Anti-ROR1 Antibody (zilovertamab vedotin) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
SEC-HPLC
The purity of Anti-ROR1 Antibody (Zilovertamab vedotin) is 98.21%, determined by SEC-HPLC.
Bioactivity: ELISA
Immobilized human ROR1 His at 2 ug/mL can bind Anti-ROR1 Antibody (Zilovertamab vedotin), The EC50 is 0.002833 ug/mL.
Bioactivity: FACS
Human ROR1 CHO-K Cell Line were stained Anti-ROR1 Antibody (zilovertamab vedotin) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, The EC50 is 0.03245 ug/mL.
Bioactivity: FACS
Human ROR1 HEK293T cells were stained with Anti-ROR1 Antibody (Zilovertamab vedotin) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, The EC50 is 0.05656 ug/ml.
Function: Internalization
The endocytosis ratio Zilovertamab by Human ROR1-HEK293T cells increased with the increase of antibody concentration, and the Internalization Rate (%) reached 80% .
Research in vivo
Anti-ROR1 Antibody (Zilovertamab vedotin) inhibited the tumor growth of MDA-MB-231on NSG mice. The result showed significant anti-tumor effects, with an tumor inhibition rate (TGI) of 96.6% at 10 mpk.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"