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Product Name
ZC3H12D antibody
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Description
ZC3H12D Rabbit Polyclonal antibody. Positive IP detected in Raji cells. Positive WB detected in Raji cells, K-562 cells. Positive IHC detected in human tonsillitis tissue. Observed molecular weight by Western-blot: 55-58 kDa
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Tested applications
ELISA, IHC, WB, IP
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Species reactivity
Human; other species not tested.
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Alternative names
C6orf95 antibody; dJ281H8.1 antibody; FLJ46041 antibody; MCP induced protein 4 antibody; MCPIP4 antibody; p34 antibody; Probable ribonuclease ZC3H12D antibody; TFL antibody; ZC3H12D antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ZC3H12D recombinant protein (Accession Number: NM_207360). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:2000
IHC: 1:20-1:200
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Validations
Raji cells were subjected to SDS PAGE followed by western blot with Catalog No:116924(ZC3H12D Antibody) at dilution of 1:600
IP Result of anti-ZC3H12D (IP:Catalog No:116924, 4ug; Detection:Catalog No:116924 1:600) with Raji cells lysate 2000ug.
Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using Catalog No:116924(ZC3H12D Antibody) at dilution of 1:50 (under 40x lens)
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Background
ZC3H12D, also named as MCP induced protein 4, is a 527 amino acid protein, which contains one C3H1-type zinc finger and belongs to the ZC3H12 family. ZC3H12D exists as three isoforms and localizes in the cytoplasm. ZC3H12D may regulate cell growth likely by suppressing RB1 phosphorylation and serves as a tumor suppressor in certain leukemia cells. ZC3H12D is expressed in normal human lymphocytes but defective in some leukemia/lymphoma cell lines.
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References
- Huang S, Liu S, Fu JJ. Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation. The Journal of biological chemistry. 290(34):20782-92. 2015.
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