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Product Name
XRN1 Polyclonal Antibody
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Description
Polyclonal antibody to XRN1
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Tested applications
WB
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Species reactivity
Human
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Alternative names
XRN1 antibody; 42979 antibody; SEP1 antibody; 5'-3' exoribonuclease 1 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic Peptide of human XRN1
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, pH7.3.
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Storage instructions
Store at 4℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:1000
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Validations
Western blot - XRN1 Polyclonal Antibody
Western blot analysis of extracts of HeLa cells, using XRN1 antibody at dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.
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Background
Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"