XPR1 Rabbit Polyclonal antibody. Positive FC detected in Jurkat cells. Positive IHC detected in human heart tissue. Positive WB detected in Jurkat cells. Observed molecular weight by Western-blot: 82-84kd
ELISA, WB, IHC, FC
Human,Mouse,Rat; other species not tested.
FLJ90308 antibody; Protein SYG1 homolog antibody; SYG1 antibody; X receptor antibody; XPR1 antibody
This antibody was obtained by immunization of XPR1 recombinant protein (Accession Number: NM_001135669). Purification method: Antigen affinity purified.
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20℃. DO NOT ALIQUOT
Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:116996(XPR1 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human heart using Catalog No:116996(XPR1 antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human heart using Catalog No:116996(XPR1 antibody) at dilution of 1:100 (under 40x lens)
1X10^6 Jurkat cells were stained with 0.2ug XPR1 antibody (Catalog No:116996, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1000.
XPR1 is a receptor for xenotropic and polytropic murine leukemia retroviruses and homolog of yeast Syg1 and plant Pi transporter PHO1 (PMID: 20633538). XPR1 has been identifies as an atypical G-protein-coupled receptor. Xenotropic or polytropic retrovirus binding to XPR1 can disrupt the cAMP-mediated signaling function of Xpr1, leading to the apoptosis of infected cells (PMID: 22090134).
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