WRW4 peptide
Not For Human Use, Lab Use Only.
Cat.#: 319063
Special Price 117.7 USD
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Product Name
WRW4 peptide
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Documents
Batch to batch variation of the purity
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Sequence Shortening
H-WRWWWW-NH2
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Sequence
H-Trp-Arg-Trp-Trp-Trp-Trp-NH2
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Length (aa)
6
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Peptide Purity (HPLC)
95.85%
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Molecular Formula
C61H65N15O6
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Molecular Weight
1104.26
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Source
Synthetic
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Form
Powder
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Description
WRW4 is a selective antagonist of formyl peptide receptor 2 (FPR2) signaling, which can inhibit WKYMVm binding to FPR2 with an C50 of 0.23 μM and can also inhibit intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide. WRW4 inhibits FPR2-mediated signaling in human neutrophils and blocks chemotactic migration and superoxide generation by amyloid β42 peptide. WRW4 can reduce Brucella proliferation in animal models.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
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References
- Bae et al (2004) Identification of peptides that antagonize formyl peptide receptor-like 1-mediating signaling. J.Immunol. 173 607 PMID: 15210823
- Kain et al (2018), Inhibition of FPR2 Impaired Leukocyte Get-in Signal and Triggers Non-Resolving Inflammation in Heart Failure. FASEB J. 32 287 PMID: 31216426
- Reyes et al (2021) Formyl peptide receptor 2 (FPR2) antagonism is a potential target for the prevention of Brucella abortus 544 infection, Immunobiology 226(3) 152073 https://doi.org/10.1016/j.imbio.2021.152073
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"