WEE2 antibody

WEE2 antibody

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• Material Safety Data Sheets (MSDS)

WEE2 Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells, human ovary tissue. Observed molecular weight by Western-blot: 63-66 kDa

ELISA, WB

Human; other species not tested.

FLJ16107 antibody; WEE1 homolog 2 (S. pombe) antibody; Wee1 like protein kinase 1B antibody; Wee1 like protein kinase 2 antibody; WEE1B antibody; Wee1B kinase antibody; WEE2 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_001105558). Purification method: Antigen affinity purified.

Polyclonal

0.1M NaHCO3, 0.1M glycine, 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

WEE2, also named as WEE1B, belongs to the protein kinase superfamily. Ser/Thr protein kinase family and WEE1 subfamily. It phosphorylates and inhibits CDK1. WEE2 may act as a negative regulator of entry into mitosis (G2 to M transition). WEE2 is conserved from yeast to humans. The aim of the present study was to determine the spatiotemporal expression pattern and the function of WEE2 during oocyte maturation in a nonhuman primate species, the rhesus macaque. Taking the long double-stranded RNA-mediated RNA interference approach, down-regulation of WEE2 led to meiotic resumption in a subset of GV oocytes even in the presence of a phosphodiesterase 3 inhibitor. Overexpression of WEE2 delays the reentry of oocytes into meiosis in both mice and monkeys. WEE2 is a conserved oocyte-specific meiosis inhibitor that functions downstream of cAMP in nonhuman primates.(PMID: 20200212) The antibody is specific to WEE2.