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Product Name
WDR45 Polyclonal Antibody
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Description
Polyclonal antibody to WDR45
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Tested applications
WB, IF
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Species reactivity
Human, Mouse, Rat
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Alternative names
WDR45 antibody; JM5 antibody; NBIA4 antibody; NBIA5 antibody; WDRX1 antibody; WIPI-4 antibody; WIPI4 antibody; WD repeat domain 45 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-360 of human WDR45 (NP_001025067.1).
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:2000
IF 1:50 - 1:100 -
Validations
Immunofluorescence - WDR45 Polyclonal Antibody
Immunofluorescence analysis of A549 cells using WDR45 antibody . Blue: DAPI for nuclear staining.
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Background
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Probably recruited to membranes through its PtdIns3P activity.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"