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VPS54 antibody

Cat.#: 116795

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Special Price 239.0 USD

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Product Information

  • Product Name
    VPS54 antibody
  • Documents
  • Description
    VPS54 Rabbit Polyclonal antibody. Positive WB detected in human brain tissue, mouse brain tissue. Positive IP detected in mouse brain tissue. Observed molecular weight by Western-blot: 111kd
  • Tested applications
    ELISA, WB, IP
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    HCC8 antibody; hVps54L antibody; SLP 8p antibody; Tumor antigen HOM HCC 8 antibody; Tumor antigen SLP 8p antibody; VPS54 antibody; VPS54L antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of VPS54 recombinant protein (Accession Number: NM_001005739). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IP: 1:200-1:1000

  • Validations

    human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:116795(VPS54 antibody) at dilution of 1:300

    human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:116795(VPS54 antibody) at dilution of 1:300

    IP Result of anti-VPS54 (IP:Catalog No:116795, 4ug; Detection:Catalog No:116795 1:300) with mouse brain tissue lysate 4000ug.

    IP Result of anti-VPS54 (IP:Catalog No:116795, 4ug; Detection:Catalog No:116795 1:300) with mouse brain tissue lysate 4000ug.

  • Background
    VPS54 is a part of the Golgi-associated retrograde protein (GARP) complex protein required for tethering and fusion of endosome-derived transport vesicles to the trans-Golgi network. It may particpate in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD.
  • References
    • Colombrita C, Onesto E, Megiorni F. TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells. The Journal of biological chemistry. 287(19):15635-47. 2012.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"