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Product Name
VPS26B antibody
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Description
VPS26B Rabbit Polyclonal antibody. Positive WB detected in human brain tissue. Observed molecular weight by Western-blot: 39kd
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
Pep8b antibody; Vesicle protein sorting 26B antibody; VPS26B antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of VPS26B recombinant protein (Accession Number: NM_052875). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:116778(VPS26B antibody) at dilution of 1:1000
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Background
In mammals, there are two paralogues of yeast Vps26, VPS26A and VPS26B (PMID: 16190980). VPS26 is a component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. VPS26A and VPS26B subunits define distinct retromer complexes (PMID: 21920005). The retromer complex is important in recycling transmembrane receptors from endosomes to the trans-Golgi network (TGN).
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References
- Gallon M, Clairfeuille T, Steinberg F. A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer. Proceedings of the National Academy of Sciences of the United States of America. 111(35):E3604-13. 2014.
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