Human SorCS1 (His Tag) recombinant protein

Human SorCS1 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

VPS10 domain-containing receptor SorCS1, also known as SORCS1 and SORCS, is a single-pass type I  membrane protein which belongs to the SORCS family and SORCS1 subfamily. SORCS1 contains five BNR repeats and one PKD domain. SorCS1 is a member of the Vps10p-domain receptor family comprised of Sortilin, SorCS1, SorCS2, SorCS3, and SorLA. The common characteristic of these receptors is an N-terminal Vps10p domain, which either represents the only module of the luminal/extracellular moiety or is combined with additional domains. Family members play roles in protein transport and signal transduction. The individual receptors bind and internalize a variety of ligands, such as neuropeptides and trophic factors, and Sortilin and SorLA mediate trans-Golgi network-to-endosome sorting. Their prominent neuronal expression, several of the identified ligands, and results support the notion that members of this receptor family have important functions in neurogenesis, plasticity-related processes, and functional maintenance of the nervous system. Sortilin and SorLA mediate intracellular protein trafficking and sorting. SorCS1 binds platelet-derived growth factor-BB (PDGF-BB) and is expressed in isoforms differing only in their cytoplasmic domains. SorCS1 binds platelet-derived growth factor, a growth factor crucial for pericyte recruitment to the microvasculature, and may thus have a role in expanding or maintaining the islet vasculature.

VPS10 domain-containing receptor SorCS1

HSORCS; FLJ41758; SORCS1; SORCS; FLJ44957; RP11-446H13.1; MSORCS; FLJ43475

Q8WY21

SORCS1; SORCS

Human Cells

A DNA sequence encoding the human SORCS1 (Q8WY21-1) extracellular domain (Ser 111-Ser 1099) was fused with a polyhistidine tag at the C-terminus and a signal peptide at the N-terminus

Human

The recombinant human SORCS1 consists of 1000 amino acids and predictes a molecular mass of 113 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhSORCS1 is approximately 130 kDa due to glycosylation

> 92 % as determined by SDS-PAGE