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Product Name
VLDLR antibody
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Description
VLDLR Rabbit Polyclonal antibody. Positive WB detected in MCF7 cells, mouse ovary tissue. Observed molecular weight by Western-blot: 160kd
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Tested applications
ELISA, WB
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Species reactivity
human, mouse, rat; other species not tested.
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Alternative names
VLDLR antibody; VLDL receptor antibody; VLDL R antibody; FLJ35024 antibody; CHRMQ1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_003383). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
MCF7 cells were subjected to SDS PAGE followed by western blot with Catalog No:116761(VLDLR antibody) at dilution of 1:300
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Background
VLDLR binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. VLDLR binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation.(cytoplasmic domain of low density ipoprotein receptor). For glycosylated, the MW of VLDLR migrates to ~160kd.
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References
- Hilliard AT, Miller JE, Fraley ER, Horvath S, White SA. Molecular microcircuitry underlies functional specification in a basal ganglia circuit dedicated to vocal learning. Neuron. 73(3):537-52. 2012.
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