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Product Name
Mouse VEGFR2/Flk-1/CD309/KDR (His Tag) recombinant protein
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Description
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as a negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and by preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.
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Protein name
Vascular endothelial growth factor receptor 2
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Protein short names
KDR; LY73; VEGFR2; VEGFR; CD309; 6130401C07; SVEGFR-2; FLK-1; FLK1; KRD-1; VEGFR-2
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Uniprot ID
P35918
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Gene Name
Kdr; Flk-1; Flk1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse KDR (P35918-1) extracellular domain (Met 1-Glu 762) was expressed, with a C-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse KDR consists of 754 amino acids and predicts a molecular mass of 84.5 KDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmKDR is approximately 100-110 KDa as a result of glycosylation.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Mouse VEGFR2 / Flk-1 / CD309 / KDR Protein (His Tag) SDS-PAGE
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