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Product Name
UXT antibody
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Description
UXT Rabbit Polyclonal antibody. Positive IP detected in mouse brain tissue. Positive WB detected in HeLa cells, mouse brain tissue. Observed molecular weight by Western-blot: 18, 45 kDa
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Tested applications
ELISA, WB, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
ART 27 antibody; Protein UXT antibody; UXT antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of UXT recombinant protein (Accession Number: NM_004182). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IP: 1:200-1:1000
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:116700(UXT antibody) at dilution of 1:400
IP Result of anti-UXT (IP:Catalog No:116700, 3ug; Detection:Catalog No:116700 1:300) with mouse brain tissue lysate 4000ug.
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Background
Ubiquitously expressed transcript (UXT) is a gene transcription regulator. It can regulate androgen receptor(AR) transcription by concerting with the coreperssor UR1. It is proposed a potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling, for UXT increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. UXT is possible a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function. It can suppresses cell transformation and mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM
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References
- Carrieri C, Cimatti L, Biagioli M. Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat. Nature. 491(7424):454-7. 2012.
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