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Product Name
USP44 antibody
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Description
USP44 Rabbit Polyclonal antibody. Positive WB detected in human placenta tissue, mouse testis tissue. Observed molecular weight by Western-blot: 81kd
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Tested applications
ELISA, WB
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Species reactivity
Human; other species not tested.
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Alternative names
Deubiquitinating enzyme 44 antibody; DKFZp434D0127 antibody; FLJ14528 antibody; Ubiquitin thiolesterase 44 antibody; USP44 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of USP44 recombinant protein (Accession Number: NM_032147). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
human placenta tissue were subjected to SDS PAGE followed by western blot with Catalog No:116683(USP44 antibody) at dilution of 1:500
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Background
USP44(Ubiquitin carboxyl-terminal hydrolase 44) belongs to a large family of cysteine proteases that function as deubiquitinating enzymes. It has a ZnF-UBP (zinc-finger ubiquitin-specific protease) domain and conserved cysteine, histidine and asparagine/aspartic acid residues characteristic of deubiquitinating enzymes. And USP44 can cleave ubiquitin from ubiquitinated substrates both in vitro and in vivo. The expression of endogenous mouse or human USP44 is very low. A localization study of USP44 showed its predominant expression in the nucleus(PMID:20402667).
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References
- Zhang Y, Foreman O, Wigle DA. USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis. The Journal of clinical investigation. 122(12):4362-74. 2012.
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