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Product Name
Human PLAUR/CD87 (His Tag) recombinant protein
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Description
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
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Protein name
Urokinase plasminogen activator surface receptor
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Protein short names
U-PAR; UPAR; PLAUR; CD87; URKR
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Uniprot ID
Q03405
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Gene Name
PLAUR; MO3; UPAR
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human UPAR isoform 1 (Q03405-1) (Met 1-Arg 303) without the pro peptide was expressed, with a carboxy-terminal polyhistidine tag.
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Protein Species
Human
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Molecular weight
The secreted recombinant human UPAR consists of 292 amino acids with the predicted molecular mass of 32.8 kDa. As a result of glycosylation, rhUPAR migrates as an approximately 48 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 98 % as determined by SDS-PAGE
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Activity
Measured by its binding ability in a functional ELISA. Immobilized human uPAR at 5 μg/ml (100 μl/well) can bind biotinylated human UPA with a linear ranger of 40-1000 ng/ml.
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Validations
Human uPAR / CD87 Protein (His Tag) SDS-PAGE
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