Mouse PLAUR/CD87 (His & Fc Tag) recombinant protein
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA.
Urokinase plasminogen activator surface receptor
Protein short names
U-PAR; UPAR; PLAUR; CD87; URKR
A DNA sequence encoding the extracellular domain (Met 1-Thr 297) of mouse PLAUR (NP_035243.1) precursor was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
The recombinant mouse PLAUR/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer consists of 522 amino acids and has a predicted molecular mass of 58 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmPLAUR/Fc monomer is approximately 80-90 kDa due to glycosylation.
> 97 % as determined by SDS-PAGE
Measured by its binding ability in a functional ELISA. Immobilized human uPA at 5 μg/ml (100 μl/well) can bind mouse PLAUR with a linear ranger of 1.6-40 ng/ml.
Mouse PLAUR / CD87 / uPAR Protein (His & Fc Tag) SDS-PAGE
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