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Product Name
Uroguanylin antibody
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Description
Uroguanylin Rabbit Polyclonal antibody. Positive IF detected in HepG2 cells. Positive IHC detected in human kidney tissue, human colon tissue, human pancreas cancer tissue, human pancreas tissue. Positive WB detected in mouse pancreas tissue, mouse colon tissue, mouse small intestine tissue, rat pancreas tissue. Observed molecular weight by Western-blot: 12-13 kDa
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Tested applications
ELISA, WB, IF, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
GCAP II antibody; GCAP II Uroguanylin antibody; Guanylate cyclase activator 2B antibody; GUCA2B antibody; UGN antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Uroguanylin recombinant protein (Accession Number: NM_007102). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
IF: 1:20-1:200
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Validations
mouse pancreas tissue were subjected to SDS PAGE followed by western blot with Catalog No:116576(Uroguanylin antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human kidney using Catalog No:116576(Uroguanylin antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human kidney using Catalog No:116576(Uroguanylin antibody) at dilution of 1:50 (under 40x lens)
Immunofluorescent analysis of HepG2 cells using Catalog No:116576(Uroguanylin Antibody) at dilution of 1:50 and and Rhodamine-labeled goat anti-rabbit IgG (red).
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Background
Uroguanylin, also named as GUCA2B, is a candidate intestinal natriuretic hormone that controls the sodium and water balance between the intestine and the kidneys. It has been reported that the uroguanylin knockout mouse exhibits elevated blood pressure. Therefore, the GUCA2B gene is thought to be a susceptibility gene for essential hypertension (EH).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"