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Product Name
UPK1A antibody
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Description
UPK1A Rabbit Polyclonal antibody. Positive IP detected in mouse bladder tissue. Positive IHC detected in human bladder tissue. Observed molecular weight by Western-blot: 29 kDa
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Tested applications
ELISA, IHC, IP
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Species reactivity
Human; other species not tested.
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Alternative names
Tetraspanin 21 antibody; Tspan 21 antibody; TSPAN21 antibody; UP1A antibody; UPIA antibody; UPK1A antibody; UPKA antibody; uroplakin 1A antibody; Uroplakin Ia antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of UPK1A recombinant protein (Accession Number: NM_007000). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IP: 1:200-1:1000
IHC: 1:20-1:200
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Validations
IP Result of anti-UPK1A (IP:Catalog No:116628, 4ug; Detection:Catalog No:116628 1:300) with mouse bladder tissue lysate 3200ug.
Immunohistochemistry of paraffin-embedded human bladder tissue slide using Catalog No:116628(UPK1A Antibody) at dilution of 1:1600 (under 10x lens)
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Background
Uroplakins are a group of urothelial differentiation-related membrane proteins. They are components of the asymmetric unit membrane (AUM), which forms the apical plaques of mammalian urothelium and is believed to play a role in strengthening the urothelial apical surface thus preventing the cells from rupturing during bladder distention (PMID: 8175808). Uroplakin-1a (UPK1A) belongs to the tetraspanin (TM4SF) family. UPK1A plays an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane.
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