-
Product Name
Rat CLEC5A / MDL1 / MDL-1 (His Tag) recombinant protein
- Documents
-
Description
CLEC5A, also known as MDL1 and MDL-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. CLEC5A with dnax-activation protein 12 and may play a role in cell activation. It also functions as a positive regulator of osteoclastogenesis. CLEC5A acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation .The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.
-
Protein name
Uncharacterized protein
-
Protein short names
CLEC5A; MEMBER A; CARBOHYDRATE-RECOGNITION DOMAIN) LECTIN; C-TYPE LECTIN SUPERFAMILY MEMBER 5; MEMBER A; CLECSF5; MYELOID DAP12-ASSOCIATING LECTIN 1; LY100; TYPE II TRANSMEMBRANE PROTEIN MDL-1; SUPERFAMILY MEMBER 5; C-TYPE LECTIN DOMAIN FAMILY 5; MDL-1; C-TYPE LECTIN DOMAIN FAMILY 5 MEMBER A; CARBOHYDRATE-RECOGNITION DOMAIN) LECTIN; MDL1; C-TYPE (CALCIUM DEPENDENT
-
Uniprot ID
F7GAV1
-
Gene Name
CLEC5A; EGK_14219
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the rat CLEC5A (F7GAV1) (Val30-Lys190) was expressed with a polyhistidine tag at the N-terminus.
-
Protein Species
Rat
-
Molecular weight
The recombinant rat CLEC5A comprises 181 amino acids and has a predicted molecular mass of 20.6 kDa. The apparent molecular mass of the protein is approximately 36 kDa in SDS-PAGE under reducing conditions.
-
Purity
> 95 % as determined by SDS-PAGE
-
Validations
Rat CLEC5A / MDL1 / MDL-1 Protein (His Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"