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Product Name
Rhesus Osteoprotegerin/TNFRSF11B (Fc Tag) recombinant protein
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Description
Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. Osteoprotegerin/TNFRSF11B acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. This protein may inhibit the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. Osteoprotegerin/TNFRSF11B also play a role in preventing arterial calcification, act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.
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Protein name
Uncharacterized protein
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Protein short names
OSTEOPROTEGERIN; TNFRSF11B; TR1; OCIF; MGC29565; OPG
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Uniprot ID
F7G7U5
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Gene Name
TNFRSF11B; EGK_19228
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rhesus TNFRSF11B (XP_001096915.1) (Met28-Leu428) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Rhesus
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Molecular weight
The recombinant rhesus TNFRSF11B comprises 621 amino acids and has a calculated molecular mass of 65 KDa.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Cynomolgus Osteoprotegerin / TNFRSF11B Protein (Fc Tag) SDS-PAGE
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