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Product Name
Anti-TNFRSF11B antibody
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Description
Rabbit polyclonal antibody to TNFRSF11B
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Tested applications
WB, ICC, IHC-P
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Species reactivity
Human, Mouse, Rat
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Alternative names
OPG antibody; TR1 antibody; OCIF antibody; PDB5 antibody
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Isotype
Rabbit IgG
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Preparation
This antigen of this antibody was recombinant protein within human osteoprotegerin aa 22-232.
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Clonality
Polyclonal
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Formulation
Liquid, 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage instructions
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
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Applications
WB: 1:500-1:2,000
ICC: 1:100-1:500
IHC-P: 1:50-1:200
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Validations
Fig1: Western blot analysis of Osteoprotegerin on 293 (1) and K562 (2) cell lysate using anti-Osteoprotegerin antibody at 1/500 dilution.
Fig2: ICC staining Osteoprotegerin in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-Osteoprotegerin antibody. Counter stained with hematoxylin.
Fig4: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-Osteoprotegerin antibody. Counter stained with hematoxylin.
Fig5: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Osteoprotegerin antibody. Counter stained with hematoxylin.
Fig6: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-Osteoprotegerin antibody. Counter stained with hematoxylin.
Fig7: Immunohistochemical analysis of paraffin-embedded mouse heart tissue using anti-Osteoprotegerin antibody. Counter stained with hematoxylin.
- Background
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References
- Bao Y et al. Topical Treatment with Xiaozheng Zhitong Paste (XZP) Alleviates Bone Destruction and Bone Cancer Pain in a Rat Model of Prostate Cancer-Induced Bone Pain by Modulating the RANKL/RANK/OPG Signaling. Evid Based Complement Alternat Med 2015:215892 (2015).
- Peng X et al. Differential expression of the RANKL/RANK/OPG system is associated with bone metastasis in human non-small cell lung cancer. PLoS One 8:e58361 (2013).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"