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Product Name
UNC13A/Munc13-1 antibody
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Description
UNC13A/Munc13-1 Rabbit Polyclonal antibody. Positive IP detected in mouse brain tissue. Positive WB detected in human brain tissue, mouse brain tissue. Observed molecular weight by Western-blot: 193-210 kDa
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Tested applications
ELISA, WB, IP
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
KIAA1032 antibody; Munc13 1 antibody; Protein unc 13 homolog A antibody; unc 13 homolog A (C. elegans) antibody; UNC13A antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_001080421). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
0.1M NaHCO3, 0.1M glycine, 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
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Validations
human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:116572(UNC13A antibody) at dilution of 1:300
IP Result of anti-UNC13A (IP:Catalog No:116572, 4ug; Detection:Catalog No:116572 1:500) with mouse brain tissue lysate 5200ug.
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Background
UNC13A, also named as KIAA1032, belongs to the unc-13 family. It plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. UNC13A is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). It is essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. UNC13A is also involved in secretory granule priming in insulin secretion. The antibody is specific to UNC13A.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"