UMPS antibody

Cat.#: 116570

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Product Information

  • Product Name
    UMPS antibody
  • Documents
  • Description
    UMPS Rabbit Polyclonal antibody. Positive IHC detected in human colon cancer tissue. Positive WB detected in HeLa cells, COLO 320 cells, human kidney tissue, Jurkat cells. Positive IP detected in HEK-293 cells. Observed molecular weight by Western-blot: 52kd
  • Tested applications
    ELISA, WB, IHC, IP
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    OMPdecase antibody; OPRT antibody; OPRTase antibody; UMPS antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of UMPS recombinant protein (Accession Number: NM_000373). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IP: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:116570(UMPS antibody) at dilution of 1:400

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:116570(UMPS antibody) at dilution of 1:400

    Immunohistochemical of paraffin-embedded human colon cancer using Catalog No:116570(UMPS antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human colon cancer using Catalog No:116570(UMPS antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human colon cancer using Catalog No:116570(UMPS antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human colon cancer using Catalog No:116570(UMPS antibody) at dilution of 1:100 (under 40x lens)

    IP Result of anti-UMPS (IP:Catalog No:116570, 3ug; Detection:Catalog No:116570 1:500) with HEK-293 cells lysate 1700ug.

    IP Result of anti-UMPS (IP:Catalog No:116570, 3ug; Detection:Catalog No:116570 1:500) with HEK-293 cells lysate 1700ug.

  • Background
    UMPS, also named as OPRT and ODC, plays an important role in pyrimidine synthesis, converting orotic acid to uridine 5′ monophosphate. UMPS has four isoforms with MW 53 kDa, 43 kDa, 33 kDa and 23 kDa.
  • References
    • Zhao HY, Ma GW, Zou BY. Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients. OncoTargets and therapy. 7:1301-10. 2014.
    • Zhao HY, Chen GY, Huang Y. Erlotinib plus capecitabine as first-line treatment for older Chinese patients with advanced adenocarcinoma of the lung (C-TONG0807): an open-label, single arm, multicenter phase II study. Medicine. 94(2):e249. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"