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UHMK1 antibody

Cat.#: 116562

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Product Information

  • Product Name
    UHMK1 antibody
  • Documents
  • Description
    UHMK1 Rabbit Polyclonal antibody. Positive IHC detected in human prostate cancer tissue. Positive WB detected in mouse thymus tissue, mouse brain tissue. Positive IP detected in mouse brain tissue. Observed molecular weight by Western-blot: 47kd
  • Tested applications
    ELISA, WB, IHC, IP
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    KIS antibody; Kist antibody; U2AF homology motif kinase 1 antibody; UHMK1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of UHMK1 recombinant protein (Accession Number: NM_144624). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IP: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    mouse thymus tissue were subjected to SDS PAGE followed by western blot with Catalog No:116562(UHMK1 antibody) at dilution of 1:500

    mouse thymus tissue were subjected to SDS PAGE followed by western blot with Catalog No:116562(UHMK1 antibody) at dilution of 1:500

    Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:116562(UHMK1 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:116562(UHMK1 antibody) at dilution of 1:50 (under 10x lens)

    IP Result of anti-UHMK1 (IP:Catalog No:116562, 4ug; Detection:Catalog No:116562 1:500) with mouse brain tissue lysate 2640ug.

    IP Result of anti-UHMK1 (IP:Catalog No:116562, 4ug; Detection:Catalog No:116562 1:500) with mouse brain tissue lysate 2640ug.

  • Background
    UHMK1, also named as KIS, or KIST, is a 419 amino acid protein, which contains one RRM (RNA recognition motif) domain, one protein kinase domain, and belongs to the protein kinase superfamily. UHMK1 is widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes. UHMK1 localizes in the nucleus and upon serum stimulation, phosphorylating CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. UHMK1 may be involved in trafficking and/or processing of RNA and may have a role in the developing nervous system and the adult brain.
  • References
    • Rowe DD, Leonardo CC, Hall AA. Cord blood administration induces oligodendrocyte survival through alterations in gene expression. Brain research. 1366:172-88. 2010.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"