-
Product Name
UGT1A1 Polyclonal Antibody
- Documents
-
Description
Polyclonal antibody to UGT1A1
-
Tested applications
WB, IF
-
Species reactivity
Human, Mouse, Rat
-
Alternative names
UGT1A1 antibody; BILIQTL1 antibody; GNT1 antibody; HUG-BR1 antibody; UDPGT antibody; UDPGT 1-1 antibody; UGT1 antibody; UGT1A antibody; UDPGT1-1 antibody; UDP-glucuronosyltransferase 1-1 antibody
-
Isotype
Rabbit IgG
-
Preparation
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human UGT1A1 (NP_000454.1).
-
Clonality
Polyclonal
-
Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
-
Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
-
Applications
WB 1:500 - 1:2000
IF 1:50 - 1:200 -
Validations
Immunofluorescence - UGT1A1 Polyclonal Antibody
Immunofluorescence analysis of U2OS cells using UGT1A1 antibody . Blue: DAPI for nuclear staining.
-
Background
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"