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Product Name
Human USP46 (SUMO Tag) recombinant protein
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Description
Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2.
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Protein name
Ubiquitin carboxyl-terminal hydrolase 46
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Protein short names
AI451644; UBIQUITIN THIOLESTERASE 46; 2410018I08RIK; UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 46; UBIQUITIN SPECIFIC PROTEASE 46; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 46; 1190009E20RIK; UBIQUITIN THIOESTERASE 46; DEUBIQUITINATING ENZYME 46
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Uniprot ID
P62069
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Gene Name
Usp46
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human USP46 [(Identical to the mouse USP46 (NP_808229.1)] (Met1-Glu366) was expressed and purified.
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Protein Species
Human
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Molecular weight
The secreted recombinant human USP46 consists of 477 amino acids and predicts a molecular mass of 55.2 KDa. The apparent molecular mass of the protein is approximately 64 Kda in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human / Mouse USP46 Protein (SUMO Tag) SDS-PAGE
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