Anti-USP46 antibody

Anti-USP46 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Human USP46

ELISA, IHC-P

Human USP46

1190009E20Rik antibody; 2410018I08Rik antibody; AI451644 antibody; deubiquitinating enzyme 46 antibody; deubiquitinating enzyme 46 antibody; ubiquitin carboxyl-terminal hydrolase 46 antibody; ubiquitin carboxyl-terminal hydrolase 46 antibody; ubiquitin specific protease 46 antibody; ubiquitin specific protease 46 antibody; ubiquitin thioesterase 46 antibody; ubiquitin thioesterase 46 antibody; ubiquitin thiolesterase 46 antibody; ubiquitin thiolesterase 46 antibody; ubiquitin-specific-processing protease 46 antibody; ubiquitin-specific-processing protease 46 antibody; AI451644 antibody; 1190009E20Rik antibody; 2410018I08Rik antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human USP46 . USP46 specific IgG was purified by Human USP46 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

USP46 belongs to the peptidase C19 family, USP12/USP46 subfamily. Deubiquitinating enzymes (DUBs) are a large group of proteases which are also commonly referred to as deubiquitinating peptidases, deubiquitinating isopeptidases, deubiquitinases, ubiquitin proteases, ubiquitin hydrolyases, ubiquitin isopeptidases, or Dubs. They regulate ubiquitin-dependent metabolic pathways by cleaving ubiquitin-protein bonds. They also may act as negative and positive regulators of the ubiquitin system. Besides ubiquitin recycling, they are also involved in processing of ubiquitin precursors, in proofreading of protein ubiquitination and in disassembly of inhibitory ubiquitin chains. USP46 is a deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. It may act by mediating the deubiquitination of GAD1/GAD67. USP46 has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity and it is not involved in deubiquitination of monoubiquitinated FANCD2.