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Product Name
Human UBASH3B / Sts1 / TULA-2 (His Tag) recombinant protein
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Description
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
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Protein name
Ubiquitin-associated and SH3 domain-containing protein B
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Protein short names
SUPPRESSOR OF T-CELL RECEPTOR SIGNALING 1; SH3 DOMAIN-CONTAINING 70 KDA PROTEIN; TULA2; CBL-INTERACTING PROTEIN P70; NM23-PHOSPHORYLATED UNKNOWN SUBSTRATE; 2810457I06RIK; T-CELL UBIQUITIN LIGAND 2; STS1; UBASH3B; TULA-2; BB125008; P70; B; UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING PROTEIN B; UBIQUITIN ASSOCIATED AND SH3 DOMAIN CONTAINING; UBIQUITIN ASSOCIATED AND SH3 DOMAIN CONTAINING B; STS-1; TYROSINE-PROTEIN PHOSPHATASE STS1/TULA2; CBL-INTERACTING PROTEIN STS-1
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Uniprot ID
Q8TF42
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Gene Name
UBASH3B; KIAA1959; STS1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human UBASH3B(Q8TF42) (Gln382-Glu649) was expressed with a polyhistide tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human UBASH3B consists of 283 amino acids and predicts a molecular mass of 32 KDa. It migrates as an approximately 30 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human UBASH3B / Sts1 / TULA-2 Protein (His Tag) SDS-PAGE
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