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Mouse SHP2 / PTPN11 (His Tag) recombinant protein

Cat.#: 502879

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Product Information

  • Product Name
    Mouse SHP2 / PTPN11 (His Tag) recombinant protein
  • Documents
  • Description
    Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.
  • Protein name
    Tyrosine-protein phosphatase non-receptor type 11
  • Protein short names
    2700084A17RIK; BPTP3; PROTEIN-TYROSINE PHOSPHATASE 1D; SAP-2; PTP-1D; NS1; PTP2C; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11; SHP-2; SHP2; PROTEIN-TYROSINE PHOSPHATASE SYP; PTP1D; AW536184; CFC; SH2 DOMAIN-CONTAINING PROTEIN TYROSINE PHOSPHATASE-2; PROTEIN-TYROSINE PHOSPHATASE 2C; SYP; SH-PTP3; SH-PTP2; PTP-2C
  • Uniprot ID
    P35235
  • Gene Name
    Ptpn11
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse PTPN11 (P35235-2) (Met1-Arg593) was expressed with a C-terminal polyhistidine tag.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse PTPN11 comprises 604 amino acids and has a predicted molecular mass of 69.5 kDa. The apparent molecular mass of the protein is approximately 65 kDa in SDS-PAGE under reducing conditions due to glycosylation.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to dephosphorylate a tyrosine residue in a peptide containing the EGFR Y992 phosphorylation site (Catalog # ES006).
    The specific activity is > 1 pmoles/min/μg.
  • Validations

    Mouse SHP2 / PTPN11 Protein (His Tag) SDS-PAGE

    Mouse SHP2 / PTPN11 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"