Mouse MERTK/Mer (Fc Tag) recombinant protein

Mouse MERTK/Mer (Fc Tag) recombinant protein

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Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Tyrosine-protein kinase Mer

MGC133349; NMF12; EYK; RP23-30M20.1; C-EYK; TYRO12; C-MER; RP38; NYK; MERTK; MER

Q60805

Mertk; Mer

Human Cells

A DNA sequence encoding the mouse MERTK (Q60805) extracellular domain (Met 1-Phe 498) was was fused with the Fc region of human IgG1 at the C-terminus.

Mouse

The secreted recombinant mouse MERTK/Fc chimera is a disulfide-linked homodimer. The reduced monomer consists of 721 amino acids and has a predicted molecular mass of 79.3 kDa. As a result of glycosylation, rm MERTK/Fc monomer migrates as an approximately 130 kDa band in SDS-PAGE under reducing conditions.

> 90 % as determined by SDS-PAGE