Human MERTK/Mer (aa 578-872) recombinant protein
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Tyrosine-protein kinase Mer
Protein short names
MER; MERTK; RP38; C-MER; TYRO12; NYK; RP23-30M20.1; C-EYK; NMF12; MGC133349; EYK
A DNA sequence encoding the human MERTK (Q12866) (Glu 578-Tyr 872) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus.
The secreted recombinant human MERTK consists of 297 amino acids and predicts a molecular mass of 34.1 KDa. The apparent molecular mass of the protein is approximately 29 KDa in SDS-PAGE under reducing conditions due to glycosylation.
> 85 % as determined by SDS-PAGE
Kinase activity untested
Human MERTK / Mer(aa 578-872) Protein SDS-PAGE
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