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Product Name
Human p63 / TP63 (His & GST Tag) recombinant protein
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Description
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.
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Protein name
Tumor protein 63
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Protein short names
SHFM4; AIS; TP73L; NBP; P63; OFC8; TP53L; TP53CP; P51; P73L; P53CP; P40; P73H; KET; B(P51B); RHS; B(P51A); EEC3; LMS
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Uniprot ID
Q9H3D4
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Gene Name
TP63; KET; P63; P73H; P73L; TP73L
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human TP63 isoform 1 (Q9H3D4-1) (Met 1-Glu 680) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human TP63/GST chimera consists of 917 amino acids and has a calculated molecular mass of 105 KDa. It migrates as an approximately 125 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human P63 / TP63 / Tumor protein p63 Protein (His & GST Tag) SDS-PAGE
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