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Product Name
Human CD137 / 4-1BB (His & Fc Tag) recombinant protein
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Description
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
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Protein name
Tumor necrosis factor receptor superfamily member 9
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Protein short names
LY63; ILA; TNFRSF9; RP23-272N19.6; A930040I11RIK; MGC2172; AI325004; CDW137; CD137; 4-1BB; AA408498
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Uniprot ID
Q07011
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Gene Name
TNFRSF9; CD137; ILA
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the N-terminal fragment (Met 1-Gln 186) of the extracellular domain of human 4-1BB (NP_001552.2) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human 4-1BB/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 409 amino acids and has a calculated molecular mass of 45.2 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh4-1BB/Fc monomer is approximately 60-65 kDa due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured by its binding ability in a functional ELISA. Immobilized recombinant mouse 4-1BB Ligand at 20 μg/ml (100 μl/well) can bind human 4-1BB with a linear range of 15.6-500 ng/ml.
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Validations
Human CD137 / 4-1BB / TNFRSF9 Protein (His & Fc Tag) SDS-PAGE
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