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Product Name
Human WARS / TrpRS (His Tag) recombinant protein
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Description
Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression.
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Protein name
Tryptophan--tRNA ligase, cytoplasmic
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Protein short names
GAMMA-2; TRYPTOPHANYL-TRNA SYNTHETASE; TRPRS; INTERFERON-INDUCED PROTEIN 53; IFI53; IFP53; TRYPTOPHAN--TRNA LIGASE; TRYPTOPHAN TRNA LIGASE 1; CYTOPLASMIC; HWRS; WRS; WARS
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Uniprot ID
P23381
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Gene Name
WARS; IFI53; WRS
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human WARS (P23381-1) (Pro2-Gln471) was fused with a polyhistide tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human WARS consists of 487 amino acids and has a calculated molecular mass of 55.2 kDa. The recombinant protein migrates as an approximately 55 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human WARS / TrpRS Protein (His Tag) SDS-PAGE
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