TRPV5 Polyclonal Antibody

Cat.#: 164894

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Product Information

  • Product Name
    TRPV5 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to TRPV5
  • Tested applications
    WB, IF
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    TRPV5 antibody; CAT2 antibody; ECAC1 antibody; OTRPC3 antibody; transient receptor potential cation channel subfamily V member 5 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human TRPV5 (NP_062815.3).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
    IF 1:10 - 1:100
  • Validations

    Western blot - TRPV5 Polyclonal Antibody

    Western blot - TRPV5 Polyclonal Antibody

    Western blot analysis of extracts of various cell lines, using TRPV5 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 90s.

    Immunofluorescence - TRPV5 Polyclonal Antibody

    Immunofluorescence - TRPV5 Polyclonal Antibody

    Immunofluorescence analysis of U2OS cells using TRPV5 antibody .

  • Background
    Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"