TRPV4 Polyclonal Antibody

TRPV4 Polyclonal Antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Polyclonal antibody to TRPV4

WB

Human, Mouse

TRPV4 antibody; BCYM3 antibody; CMT2C antibody; HMSN2C antibody; OTRPC4 antibody; SMAL antibody; SPSMA antibody; SSQTL1 antibody; TRP12 antibody; VRL2 antibody; VROAC antibody; transient receptor potential cation channel subfamily V member 4 antibody

Rabbit IgG

Antigen: A synthetic peptide corresponding to a sequence within amino acids 800 to the C-terminus of human TRPV4 (NP_067638.3).

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Store at -20℃. Avoid freeze / thaw cycles.

WB 1:500 - 1:2000

Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by heat, low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8. Together with PKD2, forms mechano- and thermosensitive channels in cilium. Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage.; Isoform 5: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli.; Isoform 2: Lacks channel activity, due to impaired oligomerization and intracellular retention.; Isoform 4: Lacks channel activity, due to impaired oligomerization and intracellular retention.; Isoform 6: Lacks channel activity, due to impaired oligomerization and intracellular retention.