TRK fused gene antibody

TRK fused gene antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

TRK fused gene Rabbit Polyclonal antibody. Positive IF detected in A549 cells. Positive IHC detected in human gliomas tissue. Positive WB detected in A549 cells, HEK-293 cells, mouse thymus tissue, PC-3 cells. Observed molecular weight by Western-blot: 55 kDa

ELISA, WB, IHC, IF

Human,Mouse,Rat; other species not tested.

FLJ36137 antibody; Protein TFG antibody; TF6 antibody; TFG antibody; TRK fused gene antibody; TRK fused gene protein antibody; TRKT3 antibody

Rabbit IgG

This antibody was obtained by immunization of TRK fused gene recombinant protein (Accession Number: XM_006713472). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Protein TFG (TRK-fused gene protein) plays a role in regulating phosphotyrosine-specific phosphatase-1 activity. Mutations in TFG may have important clinical relevance for current therapeutic strategies to treat metastatic melanoma. Defects in TFG are a cause of thyroid papillary carcinoma (TPC), a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P) is an autosomal-dominant neurodegenerative disorder characterized by widespread fasciculations, proximal-predominant muscle weakness, and atrophy followed by distal sensory involvement. Recent genetic investigation indicates that formation of TFG-containing cytoplasmic inclusions and concomitant mislocalization of TAR DNA-binding protein 43 kDa (TDP-43) underlie motor neuron degeneration in HMSN-P. Pathological overlap of proteinopathies involving TFG and TDP-43 highlights a new pathway leading to motor neuron degeneration.

• Yagi T, Ito D, Suzuki N. Evidence of TRK-Fused Gene (TFG1) function in the ubiquitin-proteasome system. Neurobiology of disease. 66:83-91. 2014.