TRIM5 antibody

TRIM5 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

TRIM5 Rabbit Polyclonal antibody. Positive WB detected in MKN-45 cells, mouse stomach tissue. Positive IHC detected in human prostate cancer tissue, human stomach tissue. Observed molecular weight by Western-blot: 46 kDa, 70 kDa

ELISA, IHC, WB

Human, Mouse; other species not tested.

RING finger protein 88 antibody; RNF88 antibody; TRIM5 antibody; TRIM5alpha antibody; tripartite motif containing 5 antibody

Rabbit IgG

This antibody was obtained by immunization of TRIM5 recombinant protein (Accession Number: NM_033092). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

TRIM5 belongs to the large tripartite motif protein family, members of which typically are composed of 3 zinc-binding domains, a RING, unique B-box type 1 and B-box type 2 domains, followed by a coiled-coil (CC) region. TRIM proteins use homomultimerization to identify specific cell compartments. TRIM5 promotes innate immune signaling and that this activity is amplified by retroviral infection and interaction with the capsid lattice. TRIM5 has 6 variants termed alpha, beta, gamma, delta, epsilon, and iota with the MW of 56 kDa, 46 kDa, 40 kDa, 37 kDa, 31 kDa and 29 kDa. TRIM5 can form homodimers (~70 kDa) and homotrimers (90-160 kDa).