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Product Name
TRIM33 antibody
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Description
TRIM33 Rabbit Polyclonal antibody. Positive WB detected in COLO 320 cells, MCF7 cells, PC-3 cells. Observed molecular weight by Western-blot: 140-150 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human; other species not tested.
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Alternative names
Ectodermin homolog antibody; FLJ32925 antibody; KIAA1113 antibody; Protein Rfg7 antibody; PTC7 antibody; RET fused gene 7 protein antibody; RFG7 antibody; TF1G antibody; TIF1 gamma antibody; TIF1G antibody; TIF1GAMMA antibody; TIFGAMMA antibody; TRIM33 antibody; tripartite motif containing 33 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_015906). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
COLO 320 cells were subjected to SDS PAGE followed by western blot with Catalog No:116312(TRIM33 antibody) at dilution of 1:500
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Background
TRIM33, also named as KIAA1113, RFG7 and TIF1G, belongs to the TRIM/RBCC family. It acts as an E3 ubiquitin-protein ligase. TRIM33 promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. It may act as a transcriptional repressor. It inhibits the transcriptional response to TGF-beta/BMP signaling cascade. TRIM33 plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3, TRIM33 stimulates erythroid differentiation of hematopoietic stem/progenitor. Defects in TRIM33 are a cause of thyroid papillary carcinoma (TPC). This antibody is specific to TRIM33.
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