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Product Name
TRIB3 antibody
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Description
TRIB3 Rabbit Polyclonal antibody. Positive IP detected in mouse liver tissue. Positive WB detected in mouse liver tissue. Observed molecular weight by Western-blot: 40-45 kDa
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Tested applications
ELISA, WB, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
C20orf97 antibody; NIPK antibody; SINK antibody; SKIP3 antibody; TRB 3 antibody; TRB3 antibody; TRIB3 antibody; Tribbles homolog 3 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of TRIB3 recombinant protein (Accession Number: NM_001301190). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
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Validations
mouse liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:116296(TRIB3 antibody) at dilution of 1:600
IP Result of anti-TRIB3 (IP:Catalog No:116296, 4ug; Detection:Catalog No:116296 1:500) with mouse liver tissue lysate 4000ug.
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Background
Tribbles homolog 3 (TRIB3) is a pseudokinase involved in the regulation of several signaling pathways involved in cell survival and/or cell stress.Whereas mRNA levels of TRIB3 are related with a poor prognosis, TRIB3 protein is associated with a good prognosis in human breast cancer patients, possibly due to the fact that TRIB3 is involved in hypoxia tolerance(PMID:21704407).
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References
- Berisha SZ, Hsu J, Robinet P, Smith JD. Transcriptome analysis of genes regulated by cholesterol loading in two strains of mouse macrophages associates lysosome pathway and ER stress response with atherosclerosis susceptibility. PloS one. 8(5):e65003. 2013.
- Riganti C, Gazzano E, Gulino GR, Volante M, Ghigo D, Kopecka J. Two repeated low doses of doxorubicin are more effective than a single high dose against tumors overexpressing P-glycoprotein. Cancer letters. 360(2):219-26. 2015.
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