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Product Name
TRA2B Polyclonal Antibody
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Description
Polyclonal antibody to TRA2B
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Tested applications
WB, IHC
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Species reactivity
Human, Mouse
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Alternative names
TRA2B antibody; Htra2-beta antibody; PPP1R156 antibody; SFRS10 antibody; SRFS10 antibody; TRA2-BETA antibody; TRAN2B antibody; transformer-2 protein homolog beta antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human TRA2B
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, pH7.3.
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Storage instructions
Store at 4℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:1000
IHC 1:20 - 1:50 -
Validations
Western blot - TRA2B Polyclonal Antibody
Western blot analysis of extracts of various cell lines, using TRA2B antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 30s.
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Background
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"