Torsin A antibody

Torsin A antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Torsin A Rabbit Polyclonal antibody. Positive IHC detected in human colon cancer tissue. Positive WB detected in mouse brain tissue, HEK-293 cells, mouse kidney tissue, mouse liver tissue, rat brain tissue. Observed molecular weight by Western-blot: 42-50 kDa

ELISA, IHC, WB

Human, Mouse, Rat; other species not tested.

DQ2 antibody; Dystonia 1 protein antibody; DYT1 antibody; TOR1A antibody; Torsin 1A antibody; Torsin A antibody; Torsin family 1 member A antibody; TorsinA antibody

Rabbit IgG

This antibody was obtained by immunization of Torsin A recombinant protein (Accession Number: NM_000113). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

TOR1A (torsin A), also known as DYT1, is a member of AAA+ family of ATPases that mediate chaperone and other functions involved in conformational modeling of proteins, protection from stress, and targeting of proteins to cellular organelles. TOR1A is a 37 kDa ATP binding protein highly expressed in hippocampus, spinal cord, kidney and liver. TOR1A primarily localizes to the ER while exposure to oxidative stress causes the redistribution to cell surface protrusions. Mutations in gene encoding TOR1A cause the most severe form of hereditary dystonia, termed early onset, generalized dystonia. Interestingly, Lewy bodies of PD patients were intensely immunoreactive for torsinA.