TORC1 antibody

TORC1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

TORC1 Rabbit Polyclonal antibody. Positive IP detected in mouse kidney tissue. Positive WB detected in mouse kidney tissue, A431 cells, Jurkat cells, L02 cells, mouse brain tissue. Observed molecular weight by Western-blot: 75 kDa

ELISA, WB, IP

Human, Mouse; other species not tested.

CRTC1 antibody; FLJ14027 antibody; KIAA0616 antibody; MECT1 antibody; TORC 1 antibody; TORC1 antibody; Transducer of CREB protein 1 antibody; WAMTP1 antibody

Rabbit IgG

This antibody was obtained by immunization of TORC1 recombinant protein (Accession Number: NM_015321). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

CRTC1, also named as MECT1, TORC1, and WAMTP1, belongs to the TORC family. It is a transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. CRTC1 acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. It enhances the interaction of CREB1 with TAF4. CRTC1 regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. It is a potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. CRTC1 is also a coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, CRTC1 involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. It may be required for dendritic growth of developing cortical neurons. This is a rabbit polyclonal antibody raised against residues near N terminus of human CRTC1.

• Ch'ng TH, DeSalvo M, Lin P, Vashisht A, Wohlschlegel JA, Martin KC. Cell biological mechanisms of activity-dependent synapse to nucleus translocation of CRTC1 in neurons. Frontiers in molecular neuroscience. 8:48. 2015.
• Brown-Borg HM. Reduced growth hormone signaling and methionine restriction: interventions that improve metabolic health and extend life span. Annals of the New York Academy of Sciences. 2015.