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Product Name
Human TLR2/CD282 (aa 1-587, His Tag) recombinant protein
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Description
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
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Protein name
Toll-like receptor 2
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Protein short names
CD282; TOLL/INTERLEUKIN-1 RECEPTOR-LIKE PROTEIN 4; TIL4; LY105; TOLL/INTERLEUKIN 1 RECEPTOR-LIKE 4
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Uniprot ID
O60603
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Gene Name
TLR2; TIL4
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human TLR2 (O60603) extracellular domain (Met 1-Arg 587) was expressed, with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The secreted recombinant human TLR2 consists of 580 amino acids and predicts a molecular mass of 65.8kDa. It migrates as an approximately 36 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 88 % as determined by SDS-PAGE
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Validations
Human TLR2 / CD282 Protein (aa 1-587, His Tag) SDS-PAGE
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