TNFAIP3 antibody

TNFAIP3 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

TNFAIP3 Rabbit Polyclonal antibody. Positive WB detected in RAW 264.7 cells, HeLa cells, Jurkat cells. Observed molecular weight by Western-blot: 90 kDa,37-40 kDa

ELISA, WB

Human,Mouse,Rat; other species not tested.

A20 antibody; OTUD7C antibody; TNF alpha induced protein 3 antibody; TNFA1P2 antibody; TNFAIP3 antibody; Zinc finger protein A20 antibody

Rabbit IgG

This antibody was obtained by immunization of TNFAIP3 recombinant protein (Accession Number: NM_001270507). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

TNFAIP3, also named A20, is a cytoplasmic zinc finger protein that inhibits nuclear factor kappa-B (NFKB) activity and tumor necrosis factor (TNF)-mediated programmed cell death. A20 is a ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities, and involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Upon T- or B-cell receptor engagement human (h) A20 is cleaved by MALT1 after arginine 439, yielding an N-terminal fragment and a C-terminal one (~37-40 kDa). This antibody, which is a rabbit polyclonal antibody raised against 350 aa of C-terminus of human TNFAIP3, can recognize full-length A20 (~90 kDa) and cleaved form (~37-40 kDa).

• Nie D, Zhang D, Dai J. Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation. Biology of reproduction. 94(2):31. 2016.