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Product Name
TMEM16A/DOG1 antibody
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Description
TMEM16A/DOG1 Rabbit Polyclonal antibody. Positive IHC detected in stromal tumor tissue, human breast cancer tissue, human colon cancer tissue, human hepat℃irrhosis tissue, human stomach cancer tissue.
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Tested applications
ELISA, IHC
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Species reactivity
Human, Rat; other species not tested.
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Alternative names
ANO1 antibody; AnOCtamin 1 antibody; DOG1 antibody; FLJ10261 antibody; ORAOV2 antibody; TAOS2 antibody; TMEM16A antibody; TMEM16A/DOG1 antibody; Transmembrane protein 16A antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of TMEM16A/DOG1 recombinant protein (Accession Number: BC027590). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:20-1:200
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Validations
Immunohistochemistry of paraffin-embedded stromal tumor tissue slide using Catalog No:116104(ANO1,DOG1 Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded stromal tumor tissue slide using Catalog No:116104(ANO1,DOG1 Antibody) at dilution of 1:50 (under 40x lens)
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Background
ANO1 also named as DOG1, ORAOV2, TAOS2 and TMEM16A, acts as a calcium-activated chloride channel. It is required for normal tracheal development. ANO1 (or DOG1) is used as an aid in the identification and diagnosis of gastrointestinal stromal tumors (GIST) within the context of an antibody panel, the patient’s clinical history, and other diagnostic tests evaluated by a qualified pathologist. The immunogen is the C-terminal of ANO1. This antibody can recognize isoform1 and isoform2 of human ANO1.
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References
- Bijos DA, Drake MJ, Vahabi B. Anoctamin-1 in the juvenile rat urinary bladder. PloS one. 9(9):e106190. 2014.
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