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Product Name
TLE1 antibody
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Description
TLE1 Rabbit Polyclonal antibody. Positive IHC detected in human gliomas tissue.
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Tested applications
ELISA, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
E(Sp1) homolog antibody; ESG antibody; ESG1 antibody; GRG1 antibody; TLE1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of TLE1 recombinant protein (Accession Number: NM_005077). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:20-1:200
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Validations
Immunohistochemical of paraffin-embedded human gliomas using Catalog No:116068(TLE1 antibody) at dilution of 1:50 (under 10x lens)
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Background
Transducin-like enhancer protein 1(TLE1) is a transcriptional corepressor. It can bind to and regress expression of many transcription factors such as NFkB, which is mediated by FOXA2, CTNNB1 and TCF family member in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Expression of TLE1 is highest in skeletal muscle and liver, moderate in placenta, heart, kidney, and spleen, and weak in all other tissues including brain.
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References
- Zhang L, Yang L, Liu X. MicroRNA-657 promotes tumorigenesis in hepatocellular carcinoma by targeting transducin-like enhancer protein 1 through nuclear factor kappa B pathways. Hepatology (Baltimore, Md.). 57(5):1919-30. 2013.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"